Storage-Induced Platelet Apoptosis Is a Potential Risk Factor for Alloimmunization Upon Platelet Transfusion
نویسندگان
چکیده
منابع مشابه
Platelet Factor 3 Based-clotting Time Assay as a Quality Marker for Long-term Storage of Platelet Concentrates
Background: Platelets rapidly lose their qualities usually after 5 day of storage. Different standard methods have been recommended to check the quality of platelets during storage which some of them show better correlation with other quality markers during storage. The purpose of this study was to demonstrate if platelet factor 3 (PF3) assay could be an indicator of storage lesion and provide ...
متن کاملPlatelet immunology and alloimmunization
Platelets express a variety of immunogenic markers on the cell surface. Some of these antigens are shared with other cell types as in the case of HLA antigens, which are shared with virtually all nucleated cells in the body, whereas others are observed to be essentially platelet specific. This chapter reviews the antigens expressed on platelets, the various patterns of alloimmunization to these...
متن کاملPlatelet Vascular Endothelial Growth Factor is a Potential Mediator of Transfusion-Related Acute Lung Injury
OBJECTIVE The occurrence of non-hemolytic transfusion reactions is highest with platelet and plasma administration. Some of these reactions are characterized by endothelial leak, especially transfusion related acute lung injury (TRALI). Elevated concentrations of inflammatory mediators secreted by contaminating leukocytes during blood product storage may contribute to such reactions, but platel...
متن کاملFlow Cytometric Measurement of CD41/CD61 and CD42b Platelet Receptors and Clotting Assay of Platelet Factor 3 During Long Term-Storage of Platelet Concentrates
Background: The purpose of the present in vitro study was to evaluate the effect of long term storage of conventional platelet concentrates (PCs) on major platelet receptors CD42b and CD41/CD61 by flow cytometry method and also measuring the overall platelet procoagulant activity status using platelet factor 3 (PF3) assay. Materials and Methods: Six random units of conventional platelet conce...
متن کاملplatelet factor 3 based-clotting time assay as a quality marker for long-term storage of platelet concentrates
background: platelets rapidly lose their qualities usually after 5 day of storage. different standard methods have been recommended to check the quality of platelets during storage which some of them show better correlation with other quality markers during storage. the purpose of this study was to demonstrate if platelet factor 3 (pf3) assay could be an indicator of storage lesion and provide ...
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ژورنال
عنوان ژورنال: Frontiers in Immunology
سال: 2018
ISSN: 1664-3224
DOI: 10.3389/fimmu.2018.01251